Substituted norbornyl and nortricyclyl derivatives and their use in perfumery

ABSTRACT

Novel derivatives of substitute norbornane and nortricyclene are derived from 5-ethylidene-2-norbornane by reaction with organic acids in the presence of protonating catalysts. The novel derivatives have the structural formlulae:   IN WHICH R1 represents an ethylidene or an ethyl group; R2 represents an acyloxy radical derived from an alkanoic acid containing up to 5 carbon atoms, a hydroxyl group, or an oxygen group; R3 represents an ethyl group; and mixtures thereof.

United States Patent 1191 1111 3,860,635

Kitchens Jan. 14, 1975.

I SUBSTITUTED NORBORNYL AND OTHER PUBLICATIONS NORTRICYCLYL DERIVATIVES AND Ch Ab t ts, 64114048g. THEIR USE IN PERFUMERY Chem. Abstracts, 62:1 l856h, [75] Inventor: Garry C. Kitchens, Wayne, N.J. Chem Abstracts 572123436 Chem. Abstracts, 58:1369d.

Berson et al., J.A,C.S., 89, May, 1967, pp. 2563-2568.

Chem. Abstracts, 55:731 lb.

{73] Assignce: Givaudan Corporation, Clifton, NJ.

[22] Filed: Oct. 6, 1969 Primary Examiner-Vivian Garner [21 i Appl' 864l58 Attorney, Agent, or Firm-Thomas Cifelli, Jr.

1521 US (:1. 260/488 B, 252/522, 260/497 R, [57] ABSTRACT 260586 R, 260% F Novel der1vat1ves of subst1tute norbornane and norm- [5} I lm. CL Cmc 35/22 C07C 35/28 C070 69/14, cyclene are derived from 5-ethylidene-2'-norbornane C07C 69/06, C070 69/24 by reaction with organic acids in the presence of pro- 158 Field Of Search 260/488 B, 489, 617 F, mating catalysts- 260/586 R, 497 R The novel derivativeshave the structural formlulae:

2 R 2 w R l R R R2 R3 A B C [56] References Cited in which UNlTED STATES N S R represents an ethylidene Or an ethyl group; 1 470199 6H9 Andrew 260M239 R represents an acyloxy radical derived from an 11641 12/65; Ste 6... ""1:1:i"""":'1:1i;;"" 2607489 nlknnnn nnin nnnnnning up no 5 nnnnn n 217311.356 3/I956 's616wa 61-61 260/410 y y g p or an yg p;

3,345,419 10/1967 'IYinsIey et aI 260/617 F R represents an ethyl group; and mlxtures thereof.

11 Claims, No Drawings SUBSTITUTED NORBORNYL AND NORTRICYCLYL DERIVATIVES AND THEIR USE IN PERFUMERY BACKGROUND OF THE INVENTION This invention is concerned with a new group of derivatives of tricyclo (2.2.1.0 heptanes and bicyclo (2.2.1) heptanes which are useful in perfumery. Included in this group are novel alcohols, esters and ketones.

Derivatives of tricyclo (2.2.1.0 heptanes (nortricyclenes) and bicyclo (2.2.1) heptanes (norbornanes) have been known for many years but none has been useful in formulating perfumes. These derivatives as described in U.S. Pat. No. 2,738,356, U.S. Pat. No. 3,345,419, British Patent Specification 717,010, J. Am Chem. Soc., 89, 2563-69 (1967), J. Am. Chem. Soc. 82, 6362-66 (1960), J. Am. Chem. Soc. 84, 3918-25 (1962), which include alcohols, esters and ketones, have camphoraceous, chemical and'pungent odors and therefore are not useful for the formulation of perfumes. It was therefore unexpected to find that our novel compounds had a wide variety of unusual, interesting, and useful odors, such as fatty, spicy, fruit-y, floral, citrus, woody, green and rosey odors. The novel compounds are useful in'the preparation ofall types of perfumes, such as colognes, single florals and fancy perfumes.

Specific evidence of the unexpected utility of the novel compounds of this invention as compared with the compounds disclosed in U.S. Pat. No. 2,738,356, is afforded by Examples X11 through XVI, infra. When the esters disclosed in U.S. Pat. No. 2,738,356, are substituted for the novel compounds of this invention, the resulting compositions have no perfume utility.

It must also be kept in mind that chemicals for perfumery use must not only possess desirable odors; they must have other properties, such as non-toxicity in the amounts used and non-sensitivity to the skin. While the novel compounds of this invention meet these requirements, this was unexpected as may be seen by reference to S. Winstein, J.A.C.S., 83, 1516 (1961) where endo isomer is formed and which is equilibrated to the more stable exo isomer, giving a mixture of the isomers.

SUMMARY OF THE INVENTION This'invention involves the provision of novel derivatives of norbornane and nortricyclene. The novel compounds are derived from the readily available, cheap, petrochemical, ethylidenenorbornene in good yields. They are therefore, cheap perfume ma'terials'which are in demand for perfume manufacture.

DETAILED DESCRIPTION OF THE lNVENTlON This invention relates to the preparation of derivatives of the commercially available hydrocarbon, 5- ethylideneZ-norbornene, which has the following structure:

The compounds of this invention are represented by the aforesaid formulae set forth under Abstract of the Disclosure.

The compounds of this invention, except for the ketones, can exist in both the endo and exo isomeric forms. This is exemplified as follows:

R endo 2 r R 2 0- 2 (R R R R R 3 H eXO eXO 8X0 endo it is reported that several derivatives with the same 0 In accordance with the process of this invention, the

ring-carbon skeleton as that of the novel compounds of this invention show skin sensitivity reactions and are quite toxic.

It is known (H. C. Brown, Chem. Eng News, 45,

87-97 (1967) that norbornadiene in the presence of novel esters of the invention are prepared by the reaction of 5-ethylidene-2-norbornene with an appropriate organic acid in the presence of protonating acids to yield a mixture of esters.

The following equation schematically illustrates the process of that part of the invention pertaining to the preparation of the novel esters herein:

H OOCR RCOOH OOCR H I II H oocR RCOOH OOCR -H H r 9 K III IV RCOOH V VI In carrying out the aforesaid process, a mixture of es- (2.2.1.0 hept-3-yl esters (I and II) are recovered unters of this invention, consisting of I through VI, i.e., changed and the endo and exo--ethylidenenorborn-2 endo and exo-6-ethyltricyclo (2.2.1.0 hept-3-yl esand 3-yl esters (III, IV, V, VI) are converted to the corters (I and II) and endo and exo-5-ethylidenenorborn-2 responding endo and exo-5-ethylnorbom-2and 3-yl esand 3-yl esters (III, IV, V, VI), is obtained. ters (VII, VIII, IX and X), respectively. The formulae In addition to the above reactions, schematically set of the latter are given below:

forth, a side reaction occurs in which a portion of the esters III, IV, V and VI is further protonated and reacts H with an additional molecule of an organic acid to form OOCR diacyloxy esters which, on heating, usually during dis- OOCR H tillation, are converted back to the monoesters (III, IV,

V, VI): I

OOCR HQ OOCRRCOOH VII VIII III, Iv, V, VI

H OOCR OOCR OOCR A; f OOCR H 0 CR K RCOOH III, Iv, v, VI

Another mixture of esters may be obtained by hydro- The preparation of the mixture of alcohols and kegenating the above mixture of esters containing I, II, III, tones, in accordance with this invention, can be repre- IV, V and VI. The endo and exo 6-ethyltricyclo sented schematically, as follows:

OOCR

H OOCR VII VIII

+ OCR \H OOCR IX X One mixture of alcohols of this invention which may be prepared is endo and exo-6-ethyltricyclo (2.2.1.0 heptan-3-ol (XI, XII) and endo and exo-S- ethylidenenorborn-Z and 3-ols (XIII, XIV, XV, XVI) XXI prepared by the saponification of the esters I, II, III, IV,

V, VI, respectively.

Another mixture of alcohols of this invention which may be prepared is endo and exo-6-ethyltricyclo (2.2.1.0 heptan-3-ol (XI, XII) and endo and exo-5-ethylnorbornan-2 and 3-oI'(XVII, XVIII, XIX, XX), prepared by the saponification of the mixture of partially hydrogenated esters I, II, VII, VIII, IX and X, respectively.

XVII XVIII XIX XX I t g).

XXIII A mixture of ketones of this invention consists of a mixture of 6-ethyl-tricyclo (2.2.1.0 heptan-3-one XXI and '5-ethyln orborn-2 and 3-bornanone XXII,

XXIII, prepared by the oxidation of the mixture of alcohols XI, XII, XVII, XVIII, XIX and XX.

In the reaction of ethylidenenorborncne .with organic acids any protonating catalyst, such as formic, sulfuric,

phosphoric, toluenesulfonic, boran trifluoride, boron trifluoride ctherate, boron trifluoride hydrate and acid resins may be used as catalysts for the reaction. In the reaction of formic acid with ethylidenenorbornene, no additional catalyst is needed.

0.1% or as high as 50%, on the aforesaid basis may be used. The use of low amounts of catalyst results in slow reactions (i.e., long reaction periods); the use of large amounts of catalyst not only may speed the reaction unduly, but is uneconomic.

The ratio of organic acid to ethylidenenorbornene is not critical. However, large molar excesses of organic acids favor the reaction. The use of 1 to moles of organic acid per mole of ethylidenenorbornene is preferred.

The reaction temperature is not critical. Temperatures of 20C or below give slow reactions while at 150C the yields are poor. Under the preferred conditions a reaction temperature to 50C to 100C is preferred.

The conditions for the saponification of the esters of this invention are not critical and can be carried out by known procedures, such as refluxing with aqueous or alcoholic sodium or potassium hydroxide.

The conditions for hydrogenation of the esters or alcohols of the invention are not critical. The hydrogenations can be accomplished without the use of a solvent or in solvents such as benzene, toluene or alcohols, with 15% Raney nickle or l2% of 5% palladium on charcoal catalyst, 50 to 250 lb. per square inch hydrogen pressure and a temperature of 50 to 150C.

The conditions for the oxidation of the alcohols to the ketones of this invention are not critical and can be carried out by any known method for the oxidation of alcohols to ketones. For example, the known use of sodium dichromate and sulfuric acid as oxidation catalyst at 3050C is preferred. I

The mixtures of this invention possess unusual odor characteristics and are valuable perfume materials. The components of the mixtures can be separated by vacuum distillation and the various isomers have very interesting odors. The products of this invention are also valuable as intermediates for the synthesis of other perfume ingredients.

The structures of the components of the mixtures of this invention are based on chemical reactions, thermodynamic considerations, physical data, such as vapor phase chromatography (VPC), infrared absorptions and nuclear magnetic resonance spectrocopy.

In order to illustrate this invention further, the following examples are given. Examples I through XI teach the preparation of the novel materials named in the titles of each of said examples. Examples XII through XVI teach perfume formulations embodying the novel materials of this invention.

EXAMPLE I 6-Ethyltricyclo (2.2.1.0 hept-3-y1 and 5-Ethylidenenorborn-2 and 3-yl Acetates.

ml. benzene were added and agitated 5 minutes. The

batch was allowed to settle and the lower acid layer separated. The acid layer was extracted 3 X 50 ml. benzene and acid layer discarded. The benzene layers combined and washed 3 X 50 ml. of water and then neutralized using 10% NaHCO The benzene was distilled off under reduced pressure leaving a residual 171.5 g. of crude esters. The crude was vacuum distilled at 6.0 mm. using a 27 cm. column packed with glass helices, and there was obtained 1) a 12 g. fraction, B.P. 2684C/6 mm., 2) 121 g. esters, B.P. 8488C/6 mm., 3) 16 g. esters, B.P. 8895C/6 mm., and 14 g. of residue.

The 121 g. esters, fraction 2, was redistilled at 5 mm. as above and gave 1) 14 g. esters B.P. 81-83C/5 mm., 2) 106 g. esters B.P. 83-94C/5 mm. and 1.5 g. residue. Redistillation of fractions 1 and 3 from the first distillation with fraction 1 of second distillation gave an additional 25.2 g. of product, which was combined with fraction 2 from the second distillation. The total yield was 131.2 g. (72.2% of theory) of desired product which analyzed as follows:

Saponification value 307.7 n 1.4737 Sp. Gr. 25C/25C 1.0127

The product possesses a green, fatty, citrus odor with a note of peach.

(Mixture): The IR-spectrum (neat) shows, among others, a strong broad band at around 5.72 1, typical for the carbonyl group in the ester, and a broad absorption in the 8p. region for acetoxy. The N.M.R.-spectrum in CDCl;, discloses the expected signals, e.g. a singlet at 2.0 ppm, typical for the methyl of the acetyl group.

Vapor phase chromatography (VPC), C SE 30 columns showed that 5 components were present in the following percentage by weight:

The hydrogenation of the mixture of this example established that the components 1 and 2, as shown by VPC were not hydrogenated and are ethyltricyclo (2.2.1.0 heptyl derivatives while components 3, 4 and 5 are unsaturated and are hydrogenated to saturated esters. Thus, components 3, 4 and 5 are ethylidenenorbornyl derivatives.

The Saponification of the desired product from the reaction of ethylidenenorbornene and acetic acid in the presence of a protonating catalyst gave a mixture of alcohols consisting, as shown by VPC, of five components:

1.11.1%, 2. 35.1% 3. 3.0% 4. 40.5% 510.3%. Hydroboration of ethylidenenorbornene gave mainly one isomer identical to component 4 in the alcohol mixture. Hydrogenation of the mixture of alcohols resulted in the hydrogenation of components'3, 4 and 5 giving a mixture shown by VPC as consisting of four components:

1. 7.0%, 2. 26.6%, 3. 48.2%, 4. 18.2% (components 3 and 4 being the hydrogenated products of 3, 4 and 5 above). The oxidation of the mixture of hydrogenated alcohols gave a mixture of ketones which was shown by VPC to consist of mainly (96.4%) of two ketones (13.8 and 82.6%) and a minor ketone (2%). This data indicated that the mixture is mainly two pairs of endo and exo isomers, one ethyltricyclo (2.2.1.0

heptyl pair, and one ethylnorbornyl pair, and one minor ethylnorbornyl pair.

The components of the mixture of the acetates were separated by vacuum distillation using a Nester/Faust NAF 100 spinning band column.

Additional data relative to the foregoing five components are given in the following table:

Saponification value 287 n 1.4728 Sp. Gr. 25C/25C 0.9923

The product has a fresh green woody odor, with notes of sassafrass, anethole, and a slightly fruity character.

Component 1 Component 2 Component 4 Component 5 Component 3 lsomer A(l) lsomer B(ll)* lsomer C(V)* lsomer D(Vl)* lsomer U(lV)* B. P. 76.5C/5 mm. 8l.5C/5 mm. 85.5C/5 mm. 86.5C/5 mm. 83.0"C/5 mm. Purity (VPC) 100% 100% 100% 100% 95% Purity" 100% 100% 100% 100% 100% n 1.4610 1.4639 1.4780 1.4788 1.4791 C 73.26 73.25 73.24 73.18 73.29 H 9.07 9.01 9.12 9.09 9.10 Calc. for C I-1,

R CH,

"From saponification value.

(Isolated Isomers): The lR-spectrum and the N.M.R. spectrum of each pure isomer show the expected bands and signals, comparable with the assigned structure and in accordance with the original mixture.

EXAMPLE ll 6-Ethyltricyclo (2.2.1.0 hept-3-yl and -Ethylidenenorborn-2 and 3-yl Propionates.

A reaction flask equipped with an agitator, thermometer, dropping funnel and a condenser is charged with 444 g. Propionic acid 12 g. Sulfuric acid 96% 2 g. Water The contents were agitated and heated to 60C and 240.4 g. ethylidenenorbornene was fed in at 60C over a 30 minute period with slight cooling. The batch was agitated at 60C for 5 hrs. 600 ml. of water and 200 ml. benzene were added and agitated 5 minutes. The batch was allowed to settle and the lower acid layer separated. The acid layer was extracted 2 X 50 ml. benzene and acid layer discarded. The benzene layers were combined and washed 3 times with 100 ml. of water and then neutralized using NaHCO The benzene was distilled off under reduced pressure leaving a residual 350 g. of crude esters. The crude was vacuum distilled at 3.0 mm. using a 37 cm. column packed with glass helices and the following fractions were collected:

Fraction 2, 285 g. was dissolved in hexane and neutralized with 10% sodium bicarbonate. The aqueous layer was withdrawn and the hexane was removed by distillation and the residual material was redistilled as above at 0.3 mm. The following fractions were collected:

1. 4.5 g., B.P. 50-5sc/0.3 mm., 2. 16 g., B.P. 58-62C/0.3 mm., 3. 241.5 g., B.P. 62-64C/0.3 mm., 4. 20 g. B.P. 6670C/0.3 mm. and 2.0 g. residue.

The redistillation of the fractions l and 3 from the first distillation and l, 2 and 4 from the second distillation) gave an additional 43.6 g. of desired product. The total yield, fraction 3, 241.5 g. plus 43.6 g. was 285.1 g. (61% of theory). The product analyzed as follows:

VPC (C SE 30 column) showed 4 components as follows:

THE IR-spectrum (neat) shows a strong band at 5.7511. typical of carbonyl absorption, and a broad band in the 8.411. region for propionate. The N.M.R. (60 mec 'CDCl shows the expected signals.

EXAMPLE lII 6-Ethyltricyclo (2.2.1 .0)hept-3-yl and S-Ethylidenenorborn-Z and 3-yl Butyrates.

Saponification value 267.2 n 1.4700 Sp. Gr. 25Cl25C 0.9796

The product has a green, fatty and buttery odor. VPC (200C, 20 M column) showed 4 components as follows:

The lR-spectrum (neat) shows a strong band at 5.78 1. typical of carbonyl absorption, and a broad band in the 8.51.1 region for butyrates. The N.M.R. (60 mec CDCl) shows the expected signals.

EXAMPLE IV -Ethyltricyclo (2.2.1.0 hept-3-yl and 5-Ethylidenenorborn-2 and 3-yl iso-Butyrates.

264.3 g. iso-Butyric acid 6.0 g. Sulfuric acid 1.0 g. Water 120.2 g. Ethylidenenorbornene was processed as described in Example 1. The crude esters amounted to 180 g. The crude was purified as described in Example II by vacuum distillation and gave 131.8 g. (63.2% of theory), B.P. 63-65C/0.6 mm., of desired product, 6.2 g. fractions, B.P. 5067C/0.6 mm. and 32.5 g. of residue. The desired product analyzed as follows:

Saponification value 266.7 n 1.4650 Sp. Gr. 25C/25C 0.9730

The odor of the product is green, fruity-rosy, resembling geranyl acetate.

VPC No. 3141 (175C, 20 M column) showed 4 components as follows:

The lR-spectrum (neat) shows a strong band at 5.72 1, typical of carbonyl absorption, and a broad doublet at 8.3 and 8.611. for iso-butyrates. The N.M.R. (60 mec CDCl shows the expected signals.

EXAMPLE V 6-Ethyltricyclo (2.2.1.0 hept-3-yl and 5-Ethylidenenorborn-2 and 3-y1 Pivalates.

306.4 g. Pivalic acid 6.0 g. Sulfuric acid (96%) 1.0 g. Water 120.2 g. Ethylidenenorbornene was processed as described in Example I. The crude esters amounted to 204 g. The crude esters were purified by vacuum distillation as described in Example 11 and gave 167.8 g. (75.3% of theory), B.P. 6769C/0.5 mm. of desired product, 9.2 g. B.P. 3372C/0.5 mm. of fractions and 15.0 g. of residue. The product analyzed as follows:

Saponification value 245.1 n 1.4645 Sp. Gr. 25C/25C 0.9521

VPC (175C, 20 M column) showed 3 components as follows:

The product possesses an oily, floral odor with a note of rose.

The lR-spectrum (neat) shows a strong band at 5.8 1, typical of carbonyl absorption, and a broad band in the 8.7 1 region for pivalates. The N.M.R. (60 mec CDCl shows the expected signals.

EXAMPLE VI 6-Ethyltricyclo (2.2.1.0 hept-3-yl and 5-Ethylidenenorborn-2 and 3-yl Formates.

A reaction flask equipped with an agitator, thermometer, dropping funnel and a condenser was charged with 70 g. of 98% formic acid and the contents were heated to 70C. 120 g. of ethylidenenorbornene was fed in over a 10 minute period and the batch was heated to 100C and agitated for 4% hours.

The batch was worked up as described in Example I and gave 146 g. of crude esters.

The crude esters were purified by vacuum distillation as described in Example 11 and gave 125.3 g. (75.3% of theory), B.P. 6971C/6 mm., of desired product, 13.3 g. of fractions, B.P. 3876C/6 mm. and 11.5 g. of resi- VPC (150C, 20 M column) showed 4 components as follows:

The product has a green, fatty, spicy, woodcamphoraceous, coriander like odor.

The lR-spectrum (neat) shows a strong band at 5.8011 typical of a carbonyl absorption, and a broad band in the 8.5 1. region for formate. The N.M.R. (60 mec CDCl shows the expected signals.

EXAMPLE VII 6-Ethyltricyclo (2.2.1.0 hept-3-yl and 5-Ethylnorborn-2 and 3-yl Acetates.

100.0 g. of a mixture of 6-ethyltricyclo (2.2.1.0 hept-3-yl and 5-ethylidenenorborn-2 and 3-yl acetates, prepared as described in Example I, and 10 g. Raney nickel catalyst were hydrogenated at 78C and 40-50 lb. hydrogen pressure for 2% hours in a Paar shaker, at which time no more hydrogen was absorbed. The hydrogen absorbed corresponded to 0.298 mole of hydrogen and the batch was 54% hydrogenated, which corresponded to the hydrogenation of the 5- ethylidenenorborn-2 and 3-yl acetates to the corresponding 5-ethylnorborn-2 and 3-yl acetates.

To test the completion of hydrogenation, the batch was filtered, 5 g. of palladium (5% on carbon) was added and the batch was hydrogenated an additional 2 hours at 78C and lb. hydrogen pressure. No additional hydrogen was absorbed.

The catalyst was removed by filtering and the crude, 99 g., was vacuum distilled at 6 mm. using a 37 cm. column packed with glass helices. There was obtained 95 g., (94% of theory), B.P. 7983C/6 mm. of desired product, 2.8 g. fractions, B.P. 76-85C/6 mm. and 1.0 g. of residue.

The product analyzed as follows:

Saponification value 299.1 n 1.4607 Sp. Gr. 25Cl25C 0.9925

VPC (150C, SE 30 column) showed 5 components as follows:

1. 9.7%, 2. 30.0%, 3. 36.6%, 4. 15.8%, 5. 7.9% The odor of the product is spicy, suggestive of anise,

' woody-pine-camphoraceous with a thujone character.

The lR-spectrum (neat) shows a strong band at 5.7511. typical of a carbonyl absorption and a broad band in the 8.1 .4 region for acetate. The N.M.R. (60 mec CDCl shows the expected signals.

EXAMPLE Vlll -6-Ethyltricyclo (2.2.1.0 hept-3-yl and 5-Ethylnorborn-2 and 3-yl Propionates.

233 g. of a mixture of -ethyltricyclo (2.2.1.0 hept-3-yl and S-ethylidenenorborn-Z and 3-yl propionates, prepared as described in Examples II, and 5 g. of 5% palladium on carbon were hydrogenated at 6070C, 40-50 lb. hydrogen pressure using a Paar shaker was added. The hydrogenation was conducted for 5 hours at which time the hydrogenation was completed. The hydrogen absorbed corresponded to 1.04 moles hydrogen and the batch was 86% hydrogenated, which corresponded to the hydrogenation of 5- ethylidenenorborn-2 and 3-yl propionates to the corresponding 5-ethylnorborn-2 and 3-yl propionates. The batch was filtered, the filter cake was washed with benzene and the benzene was removed under reduced pressure. The crude, 233 g., was vacuum distilled at 6 mm. using a 37 cm column packed with glass helices. There was obtained 231.7 g. (97.6% of theory), B.P. 99l01C/6 mm. of desired product, 0.8 g., B.P.

90105C/6 mm. and 0.5 g. residue. The product analyzed as follows:

Saponification value 285.7 n 1.4592 Sp. Gr. 0.9771

VPC (175C, SE 30 column) showed components as follows:

The IR-spectrum (neat) shows a strong band at 5.75p. typical of a carbonyl absorption and a broad band in the 8.4;1. region for propionates. The N.M.R. (60 mec CDCl shows the expected signals.

The product possesses a green fruity, woody green odor with a note of anise. The odor is similar to the odor of the propionates of Example II but softer and less green in character.

EXAMPLE IX 6-Ethyltricyclo (2.2.1.0 heptan-3-ols and S-Ethylidenenorbornan-Z and 3-ols.

100 g. of a mixture of -ethyltricyclo (2.2.1.0 hept-3-yl and S-ethylidenenorborn-Z and 3 -yl acetates, as prepared in Example I, 200 g. methanol and 137 g. of aqueous 45% potassium hydroxide were agitated and refluxed (77C) for 8 hours. 200 ml. of water was added and the methanol was distilled off to a pot temperature of 90C. 100 ml. of benzene was added and the bottom aqueous layer was separated and extracted 2 times with 50 ml. of benzene. The combined oilbenzene extracts were washed neutral with water and the benzene was removed under reduced pressure. The residual crude alcohols mixture, 75 g., was vacuum distilled at 6 mm. using a 37 cm column packed with glass v helices. There was obtained 70.6 g. (92.5% of theory) B.P. 82-85C/6 mm. of desired product, 1.5 g. of fractions B.P. 73-87C/6 mm., and 2.0 g. residue. The product analyzed as follows:

Saponification value (after acetylation) 306.7

VPC (150C, M column) showed 5 components as follows:

The product has a smooth, green, woody, and camphoraceous odor.

The lR-spectrum (neat) shows a strong band at 3.00;. typical of alcohol abosrption and a broad band in the 9.5;]. region for secondary alcohol. The N.M.R. (60 mec CDCl shows the expected signals.

EXAMPLE X 6-Ethyltricyclo (2.2.1.0 heptan-3-ols and 5-Ethylnorbornan-2 and 3-ols.

The batch was filtered and the crude alcohols mixture was distilled at 5 mm. using a 37 cm. column packed with glass helices. There was obtained 82.2 g. (94% of theory), B.P. -82C/5 mm. of desired product, 1.8 g. B.P. 7684C/5 mm. of fractions and 1.5 g. residue. The product analyzed as follows:

Saponification value after acetylation D20 EXAMPLE XI 6-Ethyltricyclo (2.2.1.0 heptan-3-one and 5-Ethylnorbornan-2 and 3-ones.

175 g. of a mixture of ethyltricyclo (2.2.1.0 heptan-3-ols and 5-ethyln0rbornan-2 and 3-ols, prepared as described in Example X, 155 g. sodium dichromate and 1135 g. water were agitated and heated to 50C. 326 g. of 62%% sulfuric acid was fed in over a 30 minute period with cooling. The batch was agitated at 50C for 4 hours. ml. of benzene was added and the layers separated. The aqueous acid layer was extracted 2 times with 100 ml. of benzene. The oil-benzene extracts were combined and washed with 50 ml. of water, neutralized with 10% sodium bicarbonate and washed neutral with water. The benzene was removed under reduced pressure leaving 156 g. of crude ketones. The crude ketones mixture was vacuum distilled using a 37 cm. column packed with glass helices. There was obtained 113.2 g. (65.5% of'theory) B.P. 59-62C/4 mm. of desired product, 1.8 g., B.P. 53100C/4 mm. of fractions, 13.5 g., B.P. 8398C/0.5 mm., of fractions and 26.0 g. residue. The product analyzed as follows:

EXAMPLE XII The mixture of 6-ethyltricyclo (2.2.1.0 hept-3-yl and 5-ethylidenenorborn-2 and 3-yl acetates, Example I, has a green, fruity, slightly fatty odor and was found to blend well with pine notes, such as bornyl and isobornyl acetates. Said mixture of acetates was incorporated into the following pine scent formation to the extent of 3% by weight:

Bornyl acetate 144.0 Copaiba oil 820 Fir balsam 131.0 B-Ionone 7.0 Isobornyl acetate 400.0

Labdanum absolute -Continued Lavander oil 41.0 Linalool 70.0 Linalyl acetate 33.0 Patchouli oil 8.0 Isocamphylcyclohexanol 33.0 Vanillin 10% in diethyl phthalate 3.0 Ylang bourbon 8.0 Aeetates, Example I 30.0

The incorporation of the acetates of Example I into the above pine perfume gas added lift and produced an interesting and original note which was a material improvement over the fragrance without these acetates. The acetates of Example I may be used from 0.1 to 10% in most perfume compositions and higher concentrations, greater than 50%, in order to obtain special effects.

EXAM PLE XIII The mixture of 6-ethyltricyclo (2.2.1.0 hept-3-yl and 5-ethylidenenorborn-2 and 3-yl propionates, Example II, has a fresh green woody odor with a slightly fruity character. These propionate esters were found to blend well with heliotropin and anisic aldehyde notes and were incorporated into the following heliotrope base to the extent of 1% by weight:

Anisic aldehyde Diethyl phthalate 500 Geraniol 20 I-Ieliotropin 250 Musk xylol 10 Orange oil 20 Peru balsam 20 Rose otto Bulgarian 10 Vanillin 150 Propionates, Example 11 10 The use of the propionates, Example II, in the above formulation enhanced and brightened the floral character of the fragrance and produced a pleasing effect which was not obtained when these propionates were omitted.

The propionate esters may be used from 0.1 to 10% in most perfume compositions; however, higher concentrations may be used to produce special effects.

EXAMPLE XIV The mixture of 6-ethyltricyclo (2.2.1.0 hept-3-yl and S-ethylnorbom-Z and 3-yl propionates, Example VIII, has a soft woody odor with a slightly green fruity character and blends well in perfume formulations. The propionate esters were incorporated in the following Jasmin perfume to the extent of 5% by weight:

Hydroxycit ronellal-methylantrranilate The presence of the propionate esters of Example VIII in the above Jasmin formulation contributes a very pleasant fruity, woody character to the top note which is a material improvement over the formulation without the propionates. These propionate esters may normally be used from 0.1 to 10% in most perfume compositions. They may be used in higher concentrations where special effects are desired.

EXAMPLE XV The mixture of 6-ethyltricyclo (2.2.1.0 heptan-3- ols and 5-ethylidenenorbornan-2 and 3-ols, Example IX, and the mixture of 6-ethyltricyclo (2.2.1.0 heptanols and 5-ethylnorbornan-2 and 3-ols, Example X, have similar strong, green, woody odors and are valuable perfume materials. They blend well with formulations containing coumarins and amyl salicylate.

The above alcohols of Examples IX and X were formulated in the following Fougere base to the extent of 5% by weight:

Amyl salicylate I21 Benzyl acetate 364 Bergamot oil 242 Coumarin 121 Lavender oil 12 Linalyl acetate 12 Must ambrette 24 Oak moss, 10% in diethyl phthalate 12 Patchouli oil 6 Isocamphylcyclohexanol 24 Vanillin, 10% in diethyl phthalate 12 Alcohols, Example IX or alcohols Example X 50 1000 The use of the alcohols, Example IX or the alcohols of Example X in the above Fougere base added strength and lift to the fragrance while producing an interesting and original woody note. This interesting odor effect would be difficult to produce by the use of the existing perfume materials.

Th alcohols may be used from 0.1 to 10% in perfume compositions.

EXAMPLE XVI The mixture of ketones, 6-ethyltricyclo (2.210) heptan-S-one and 5-ethylnorboman-2 and 3-ones, Example XI, has a powerful green woody odor and blends well with carvones, coumarins and amyl salicylate. The ketones were formulated in the following Fougere base to the extent of 2% by weight:

Amy] salicylate 124 Benzyl acetate 345 Bergamot oil 230 l-Carvone Coumarin 124 Lavender oil 12 Linalyl acetate 1 l musk ambrette 23 Oak moss, 10% in diethyl phthalate 11 Patchouli oil 5 Isocamphylcyclohexanol 23 Vanillin, 10% in diethyl phthalate l2 Ketones, Example XI 20 1000 The incorporation of the ketones, Example XI, into the above Fougere base added body and strength to the fragrance and enhanced the carvone note. The fragrance without the ketones is not pleasing nor strong, as is the one containing the ketones. The ketones may be used in concentrations varying from 0.1 to in perfume compositions.

The materials made in accordance with Examples III to VII, inclusive, may be substituted for the other esters of this invention in the formulations set forth in Examples XII to XIV, with substantially the same results, it

being understood that each of the esters imparts its own characteristic nuance to the formulation.

The materials made in accordance withExamples III to VII, inclusive, may be used inamounts from about 0.1 to 10%, by weight, of the perfume formulations. If desired, greater amounts, for example, around 50%, or even higher, on the same basis, may be used.

What is claimed is:

l. A compound having the formula:

wherein R is an ethylidene radical;

R is a member selected from the group consisting of an acyloxy radical derived from an alkanoic acid containing up to 5 carbon atoms, and a hydroxyl radical.

R is an ethyl group; and mixtures of said compounds.

2. A mixture in accordance with claim 1, of (a) a compound where R is acetoxy and R is ethyl, (b) a compound where R is ethylidene and R is Z-acetoxy and (c) a compound where R is ethylidene and R is 3-acetoxy.

3. A compound in accordance with claim 1, in the endo form, wherein R is ethylidene and R is 3- acetoxy.

4. A compound in accordance with claim 1, in the exo form, wherein R is ethylidene and R is 3-acetoxy.

5. A compound in accordance with claim 1, wherein R is ethylidene and R is 2-acetoxy.

6. A mixture in accordance with claim 1 of (a) a compound wherein R is propionyloxy and R is ethyl, (b) a compound wherein R is ethylidene and R is 2- propionyloxy, and (c) a compound wherein R is ethylidene and R is 3propionyloxy, all of said compounds being present in the endo and exo forms.

7. A mixture in accordance with claim 1 of (a) a compound wherein R is butyryloxy and R is ethyl, (b) a compound wherein R is ethylidene and R is 2- butyryloxy, and (c) a compound wherein R is ethylidene and R is 3-butyryloxy, all of said compounds being present in the endo and exo forms.

8. A mixture in accordance with claim I of (a) a compound wherein R is isobutyryloxy and R is ethyl, (b) a compound wherein R is ethylidene and R is 2- isobutyryloxy, and (c) a compound wherein R is ethylidene and R is 3-isobutyryloxy.

9. A mixture in accordance with claim 1 of (a) a compound wherein R is (CI-I9 CCOO- and R is ethyl, (b) a compound wherein R is ethylidene and R is 2-CH CCOO-, and (c) a compound wherein R is ethylidene and R is 3-(CH CCOO-.

10. A mixture in accordance with claim 1 of (a) a compound wherein R is formyl and R is ethyl, (b) a compound wherein R is ethylidene and R is 2- formyloxy, and (c) a compound wherein R is ethylidene and R is 3-formyloxy.

11. A mixture in accordance with claim 1 of (a) acompound wherein R is OH and R is ethyl, (b) a compound wherein R is ethylidene and R is 2-OH, and (c) a compound wherein R is ethylidene and R is 3-OH.

UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent NO. Dated January Inventor(s) IY Kitchens It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:

born.:a.none" shauld read one ,ed and sealed this 24th day of June 1975.

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fittest:

C. E'IARSHALL DANN RUTH C. I-IASON Commissioner of Patents Attesting Offlcer and Trademarks F ORIYj POJOSO (10-69) U 5 'iGVEH- MENI PRINTING OFFICE: 

2. A mixture in accordance with claim 1, of (a) a compound where R2 is acetoxy and R3 is ethyl, (b) a compound where R1 is ethylidene and R2 is 2-acetoxy and (c) a compound where R1 is ethylidene and R2 is 3-acetoxy.
 3. A compound in accordance with claim 1, in the endo form, wherein R1 is ethylidene and R2 is 3-acetoxy.
 4. A compound in accordance with claim 1, in the exo form, wherein R1 is ethylidene and R2 is 3-acetoxy.
 5. A compound in accordance with claim 1, wherein R1 is ethylidene and R2 is 2-acetoxy.
 6. A mixture in accordance with claim 1 of (a) a compound wherein R2 is propionyloxy and R3 is ethyl, (b) a compound wherein R1 is ethylidene and R2 is 2-propionyloxy, and (c) a compound wherein R1 is ethylidene and R2 is 3propionyloxy, all of said compounds being present in the endo and exo forms.
 7. A mixture in accordance with claim 1 of (a) a compound wherein R2 is butyryloxy and R3 is ethyl, (b) a compound wherein R1 is ethylidene and R2 is 2-butyryloxy, and (c) a compound wherein R1 is ethylidene and R2 is 3-butyryloxy, all of said compounds being present in the endo and exo forms.
 8. A mixture in accordance with claim 1 of (a) a compound wherein R2 is isobutyryloxy and R3 is ethyl, (b) a compound wherein R1 is ethylidene and R2 is 2-isobutyryloxy, and (c) a compound wherein R1 is ethYlidene and R2 is 3-isobutyryloxy.
 9. A mixture in accordance with claim 1 of (a) a compound wherein R2 is (CH3)3 CCOO- and R3 is ethyl, (b) a compound wherein R1 is ethylidene and R2 is 2-CH3)3 CCOO-, and (c) a compound wherein R1 is ethylidene and R2 is 3-(CH3)3CCOO-.
 10. A mixture in accordance with claim 1 of (a) a compound wherein R2 is formyl and R3 is ethyl, (b) a compound wherein R1 is ethylidene and R2 is 2-formyloxy, and (c) a compound wherein R1 is ethylidene and R2 is 3-formyloxy.
 11. A mixture in accordance with claim 1 of (a) a compound wherein R2 is OH and R3 is ethyl, (b) a compound wherein R1 is ethylidene and R2 is 2-OH, and (c) a compound wherein R1 is ethylidene and R2 is 3-OH. 